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1: Nicotine Tob Res. 2003 Feb;5(1):131-3. Related Articles, Links

Seizure associated with sleep deprivation and sustained-release bupropion.

Oncken CA, Duckrow RB.

Department of Medicine and Obstetics and Gynecology, University of Connecticut School of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030-3940, USA.

This case report describes a generalized seizure associated with sustained-release bupropion use and sleep deprivation. The subject, a 31-year-old female smoker, was participating in a clinical trial evaluating an investigational medication for smoking cessation that used sustained-release bupropion as an active control. After 5 weeks of bupropion use, the subject experienced a generalized tonic clonic seizure after staying up nearly all night packing and moving to a new residence. The patient had no other risk factors for seizures. We suggest that sleep deprivation may add to the risk of bupropion-associated seizures.

Publication Types:
  • Case Reports

PMID: 12745515 [PubMed - indexed for MEDLINE]