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Sertraline-associated syndrome of
inappropriate antidiuretic hormone: case report and review of the
literature.
Bradley ME, Foote EF, Lee EN, Merkle
L.
Department of Pharmacy Practice and Administration,
College of Pharmacy, Rutgers, State University of New Jersey, Piscataway
08855-0789, USA.
Selective serotonin reuptake inhibitors have
gained widespread use in the treatment of depression. A 78-year-old
woman became hyponatremic 3 days after being treated with sertraline and
was subsequently diagnosed with the syndrome of inappropriate
antidiuretic hormone (SIADH). She became symptomatic, but experienced
rapid resolution of the laboratory and clinical abnormalities associated
with SIADH on discontinuing sertraline and receiving fluid restriction,
hypertonic saline, and demeclocycline. Several mechanisms may relate
SIADH and vasopressin release to serotonin.
Publication Types:
- Case Reports
- Review
- Review Literature
PMID: 8840376 [PubMed - indexed for
MEDLINE]
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