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1: J Clin Pharm Ther. 2001 Apr;26(2):111-2. Related Articles, Links
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Parkinsonism and Parkinson's disease associated with long-term administration of sertraline.

Pina Latorre MA, Modrego PJ, Rodilla F, Catalan C, Calvo M.

Department of Neurology, 'Obispo Polanco' General Hospital, Teruel, Spain.

Sertraline, a serotonin reuptake inhibitor, has been used to treat depression and has rarely been associated to Parkinsonism. The disease usually appears in old people a few days after sertraline administration and disappears very quickly after its withdrawal. We report a case of a woman, 81-year-old, who presented with hemiparkinsonism after long-term administration of sertraline at a dose of 100 mg/day. The symptoms disappeared 3 months after the withdrawal of the drug. However, without further administration of the drug for 14 months, the patient presented with Parkinson's disease, but responded well to levodopa.

Publication Types:
  • Case Reports

PMID: 11350533 [PubMed - indexed for MEDLINE]