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Myoclonus during
prolonged treatment with sertraline in an adolescent
patient.
Ghaziuddin N, Iqbal A, Khetarpal
S.
Division of Child and Adolescent Psychiatry, University of
Michigan, Ann Arbor 48109-0390, USA. neerag@umich.edu
A
15-year-old female adolescent with depression developed myoclonus after
uninterrupted treatment with sertraline over 6 years. She was also
receiving methylphenidate. Withdrawal of sertraline and continuation of
methylphenidate did not result in any improvement. Treatment with
valproic acid resulted in improvement of the movement disorder. This
report suggests that myoclonus may be a side effect of sertraline in
some adolescents. Further, we hypothesized that extended treatment over
several years, young age, and a compromised central nervous system due
to underlying disorders may be risk factors for the development of this
side effect.
Publication Types:
PMID: 11436961 [PubMed - indexed for
MEDLINE]
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