Generalized pustular and erythrodermic psoriasis associated with bupropion treatment - Br J Dermatol, Vol 146, Issue 6, pp. 1061-1063 (Abstract)

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British Journal of Dermatology
Volume 146 Issue 6 Page 1061 - June 2002
doi:10.1046/j.1365-2133.2002.04679.x

CASE REPORT

Generalized pustular and erythrodermic psoriasis associated with bupropion treatment

N.H. Cox, P.M. Gordon* and H. Dodd

SummarySevere drug eruptions may cause diagnostic and therapeutic difficulty when they mimic or provoke endogenous patterns of dermatosis. We report three patients with known psoriasis in whom use of bupropion (Zyban^®), prescribed to assist with cessation of smoking, led to severe pustular or erythrodermic exacerbation of psoriasis within 3-5 weeks. All patients were systemically unwell and required hospitalization to control the disease flare.

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Authors:

N.H. Cox

P.M. Gordon

H. Dodd

Key words:

bupropion

cigarette smoking

drug eruption

psoriasis

Accepted for publication 15 November 2001

Affiliations

Department of Dermatology, Cumberland Infirmary, Carlisle CA2 7HY, U.K.*Department of Dermatology, Raigmore Hospital, Inverness IV2 3UJ, U.K.Department of Dermatology, Princess Alexandra Hospital, Harlow CM20 1QX, U.K.

Correspondence

Correspondence: Dr N.H.Cox. E-mail: Neil.Cox@ncumbria-acute.nhs.uk

To cite this article
Cox, N.H., Gordon, P.M. & Dodd, H. (2002)
Generalized pustular and erythrodermic psoriasis associated with bupropion treatment.
British Journal of Dermatology 146 (6), 1061-1063.
doi: 10.1046/
j.1365-2133.2002.04679.x