By Charly Groenendijk           Back to Side-Effects
The Netherlands
2000 - 2009

Wellbutrin or Zyban (Bupropion) Side-Effects

"Who does Not Know the Truth, is simply a Fool...
Yet who Knows the Truth and Calls it a Lie, is a Criminal."
- In "Galileo Galilei" by Berthold Brecht (1898-1956)
Take notice that also non SSRI anti-depressants (and even Ritalin) may interact (primary or secondary) with the serotonergic (or serotoninergic) system in the brain. Every medication -especially SSRI Anti-depressants- boosting serotonin activity in the brain, has potential to induce the very dangerous and potentially fatal hyperserotonergic state of the Serotonin Syndrome.

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Wellbutrin or Zyban side-effects
Bupropion  Info: Physicians

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Go to Introduction Antidepressants Negative personality and perception changes, physical changes and more
Go to Antidepressant Casualties in the Media Aggression, Violent Behaviour, Homicide, Suicide and Self-Harm
Go to Recent Media Articles SSRI/SSNRI Anti-depressants Pharmaceutical Fraud & Corruption at FDA in 2004
Go to General Side-Effects SSRI/SNRI/SSNRI Antidepressants Medical Review & Reports, Cases and Studies

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Wellbutrin/Zyban (bupropion): Medical Reports, Cases & Reviews

2004	09/14	FDA US		Antidepressant "BLACK BOX WARNING" On Suicidality Risk Recommended
2004	06/08	HealthCanada		ZYBAN WARNING: Risk of suicide, self-harm, behavioural/emotional changes
2004	03/00	Case/Review		Bupropion and its active metabolites are present in breast milk
2004	02/00	Case/Review		A Case Report of Mania Related to Discontinuation of Bupropion Therapy
2003	11/00	Case/Review		Bupropion-overdose: Patient suffered from Prolonged Symptoms & Seizures
2003	09/00	Case/Review		Bupropion-induced Somnambulism (sleepwalking) & Amnesia
2003	07/22	Case/Review		Bupropion: Tremors, Agitation, Confusion, Insomnia & Rash
2003	07/08	Case/Review		Bupropion overdose: QTc Prolongation and its clinical significance
2003	05/00	Case/Review		Bupropion-induced Rash with Eosinophilia & Systemic Symptoms Syndrome
2003	02/00	Case/Review		Seizure associated with sleep deprivation and sustained-release Bupropion
2003	02/00	Case/Review		Acute Liver Failure with concurrent Bupropion and carbimazole therapy
2003	01/00	Case/Review		Bupropion: Thrombotic Thrombocytopenic Purpura-hemolytic Uremic Syndrome
2002	11/00	Case/Review		Wellbutrin/Zyban...is there a cause for concern?
2002	11/00	Case/Review		Cardiotoxicity following Wellbutrin/Zyban overdose
2002	09/03	Case/Review		Drug safety without borders: Concerns about Wellbutrin/Zyban
2002	08/00	Case/Review		Acute Myocardial Infarction following bupropion (Zyban)
2002	06/00	Case/Review		Generalized Pustular & Erythrodermic Psoriasis associated with Bupropion
2002	06/00	Case/Review		Bupropion-induced Change CYP2D6 Extensive Metabolizer to Poor Metabolizer
2002	04/00	Case/Review		Bupropion common cause of Seizures presenting to Emergency Department
2002	02/00	Case/Review		Bupropion-induced Acute Dystonia
2002	01/00	Case/Review		Bupropion (Wellbutrin/Zyban) Toxicity
2002	01/00	Case/Review		Severe Cardiac Arrhythmias, Tachycardia, Hallucinations, Convulsions (Seizures)
2002	01/14	Case/Review		Acute Psychosis after Administration of Bupropion Hydrochloride (Zyban)
2002	01/11	Case/Review		Bupropion Poisoning/Toxicity: a case series
2001	11/00	Case/Review		Acute Cholestatic Hepatitis induced by Bupropion. A case report
2001	09/10	Case/Review		Bitemporal Epileptiform Discharges induced by Bupropion: a case report
2001	04/00	Case/Review		14-year-old boy who ingested 1.5 to 3 g of Bupropion in a Suicide Attempt
1999	05/00	Case/Review		Ileus as a Possible Result of Bupropion in an Elderly Woman
1997	00/00	Case/Review		Fatal Bupropion-overdose
1996	10/00	Case/Review		Accumulation of Bupropion after CYP2D6 inhibition may contribute to Toxicity
1995	06/00	Case/Review		Use of Bupropion involves a Higher Seizure Risk
1994	03/00	Case/Review		Bupropion-overdose: Grand Mal Seizures & Sinus Tachycardia
1986	08/00	Case/Review		A case of Bupropion-induced Seizure
1986	06/00	Case/Review		Marketing of Bupropion in US was delayed after Epileptic Seizures in clinical trials
1982	09/00	Case/Review		Perceptual Changes with Bupropion

No Abstract, more side-effects...

2004	02/15	Case/Review		Illness Similar to Serum Sickness and Bupropion
2003	10/00	Case/Review		Muscle Injury associated with Bupropion therapy
2003	02/00	Case/Review		Bupropion: Urticaria (hives or "wheals", pale red swellings of skin): 2 cases
2003	02/00	Case/Review		Ballism (abnormal swinging jerking movements) associated with Bupropion use
2003	02/28	Case/Review		Convulsive Episode (seizures) with Bupropion in patient not included in risk group
2003	01/00	Case/Review		General. Acute Urticaria (hives or "wheals", pale red swellings of skin): 8 cases
2002	12/00	Case/Review		Bupropion: Aquagenic Pruritus (intense itching by brief contact with water)
2002	12/00	Case/Review		Seizure & Cardiac Arrest during Bupropion SR treatment
2002	09/19	Case/Review		Seizure induced by insufflation of Bupropion
2002	08/00	Case/Review		Death on Bupropion (ex amfebutamone)
2002	06/15	Case/Review		Serum Sickness-like Reaction induced by Bupropion
2002	04/00	Case/Review		Convulsions (seizures) & Hypersensitivity Reactions linked to Bupropion
2002	01/08	Case/Review		Bupropion (Zyban, Wellbutrin SR): reports of Deaths, Seizures & Serum Sickness
1999	12/00	Case/Review		Bupropion: Myocardial Infarction, Seizure & Abnormal Head CT Scan

Wellbutrin/Zyban Articles

2002	02/25	icNewcastle		Wellbutrin/Zyban Ban Call
2002	02/22	Reuters Health		EU Agency to Review Zyban Smoking Cessation Drug
2002	02/08	Frankfurter		Doctors' Warning About Wellbutrin/Zyban
2002	01/11	IrishMed.Journ.		Bupropion (Zyban or Wellbutrin) Toxicity
2001	10/11	ThisIsLondon		Bupropion (Zyban or Wellbutrin) Banned in France
2001	09/27	New Z. Herald		Wellbutrin/Zyban pill Relegated
2001	06/18	TheAge.com.au		Almost 800 Adverse Reactions to Wellbutrin/Zyban since February in Australia
2001	02/18	BBC News		Deaths 'linked to smoking drug' Zyban (Wellbutrin)
2000	09/09	ADF Archive		Extensive Research into GlaxoSmithKline & Side Effects Wellbutrin/Zyban

Anti-Depressant Neurological Side-Effects:		Addiction & Withdrawal
Anti-Depressant Neurological Side-Effects:		Akathisia & Mania (Suicide & Aggression)
Anti-Depressant Neurological Side-Effects:		Serotonin Syndrome
Anti-Depressant Neurological Side-Effects:		Toxicity & Brain Damage
Anti-Depressant Neurological Side-Effects:		"Anecdotal" Reports -Personal Experiences

Antidepressants:		How To Wean/Taper Off
Antidepressants:		How to Survive a Negative Reaction
Antidepressants:		Conquering Depression and Anxiety