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All Truth passes through Three Stages: First,
it is Ridiculed. Second, it is Violently Opposed... Third, it is Accepted as being Self-Evident.
- Arthur Schopenhauer (1778-1860) By Charly Groenendijk           Back to Side-Effects
The Netherlands
2000 - 2009

 
  Prozac or Sarafem (Fluoxetine) Side-Effects  
 

"Who does Not Know the Truth, is simply a Fool...
Yet who Knows the Truth and Calls it a Lie, is a Criminal."
- In "Galileo Galilei" by Berthold Brecht (1898-1956)

Take notice that also non SSRI anti-depressants (and even Ritalin) may interact (primary or secondary) with the serotonergic (or serotoninergic) system in the brain. Every medication -especially SSRI Anti-depressants- boosting serotonin activity in the brain, has potential to induce the very dangerous and potentially fatal hyperserotonergic state of the Serotonin Syndrome.
Prozac or Sarafem severe physical & mental side-effects
Fluoxetine  Info: Physicians
Oct 14, 2004: Prozac Exposed - Your Wonder Drug to Hell!
Sign the Petition Against Prozac (Sarafem, fluoxetine)
Go to Introduction Antidepressants Negative personality, perception & physical changes
Go to Antidepressant Casualties in the Media Aggression, Homicide, Suicide & Self-Harm
Go to Recent Media Articles (SSRI) Antidepressants Pharmaceutical & FDA Fraud in 2004
Go to General Side-Effects SSRI/SSNRI Antidepressants Medical Review, Cases & Studies
Tardive Dyskinesia/Dystonia, Parkinsonism & Akathisia
Prozac (Sarafem, fluoxetine) induced side-effects (Iatrogenic Extrapyramidal Symptoms) are recognized to be similar to Neuroleptic (anti-psychotic) induced side-effects. These side-effects are known as Tardive Dyskinesia/Dystonia (severe body movement disorder, mostly permanent), Parkinsonism (a sign of future Parkinson's disease) and Akathisia (a Neurological driven severe mania/agitation that can lead to suicidality, suicide attempts, self-harm & suicide). It is well documented in the medical literature that these neuroleptic induced side-effects refer to damage at dopaminergic neurons in the "motor system" of the
"Basal Ganglia", a structure deep in the "Limbic System" of the brain. 1, 2, 3, 4, http://www.emedicine.com/EMERG/topic338.htm (scroll down)

Serotonin Syndrome
The Serotonin Syndrome is a potentially lethal condition caused by excessive serotonergic activity It is a very dangerous and a potentially fatal side effect of the serotonergic enhancing drug (SSRI) Prozac and is diagnosed by the presence of at least 3 of 10 symptoms: mental status changes (confusion, hypomania), agitation, myoclonus, hyperreflexia, diaphoresis, shivering, tremor, diarrhea, incoordination, and fever. This "hyperserotonergic" toxic condition requires heightened clinical awareness in order to prevent, recognize, and treat the condition promptly. Promptness is vital because, as we just mentioned, the serotonin syndrome can be fatal and death from this side effect can come very rapidly. The Serotonin syndrome is brought on by excessive levels of serotonin and is difficult to distinguish from the "Neuroleptic Malignant Syndrome" because the symptoms are so similar. The "Neuroleptic Malignant Syndrome" is a serious condition brought on by the use of neuroleptic drugs (anti-psychotics).
Source: Prozac: Panacea or Pandora? by Dr Ann Blake Tracy http://members.aol.com/atracyphd/syndrome.htm
Source: Journal of Clinical Psychiatry

MEDICAL REPORTS OF PROZAC (FLUOXETINE) INDUCED (IATROGENIC) SEVERE SYMPTOMS:

DEATH
2000 
04/00
 Case/Review Child, 9; liver cytochrome P-450 2D6 deficiency; Prozac-related death
1994 
02/00
 Case/Review Fluoxetine and Violent Death in Maryland: violent methods in fluoxetine suicides
1991 
09/00
 Case/Review Unexpected Deaths in depressed medical inpatients treated with Fluoxetine

NEWBORN BABY (NEONATAL) NEUROLOGICAL DAMAGE & WITHDRAWAL
2004 
08/09
 Health Canada WARNING: Neurological Adverse Effects of Prozac on Newborns
2004 
08/00
 Case/Study Using an SSRI (such as Prozac) during pregnancy has Damaging Effects on Fetus
2004 
06/00
 Case/Review Baby Prozac (withdrawal) side-effects: agitation, breathing & suction problems
2004 
02/00
 Case/Study SSRI's (such as Prozac) during pregnancy: Foetal Brain Damage (Disruptions)
2003 
08/00
 Case/Review Baby Prozac side-effects: hypoglycaemia, bradycardia, tachycardia, jaundice
2003 
07/00
 Case/Review Increased risk for neonatal problems after exposure to Prozac in late pregnancy
2003 
07/14
 Case/Review Prozac During Pregnancy May Cause Neurologic Symptoms in Newborns
2001 
03/00
 Case/Review Baby Prozac withdrawal syndrome lasting up to one month after birth
2001 
03/00
 Case/Review BABY Withdrawal Syndrome after exposure to SSRI's Celexa, Paxil & Prozac
2000 
10/11
 Case/Review Prozac Toxicity in BABY: marked motor automatism & skin manifestations
1999 
11/00
 Case/Study Breastfeeding while taking Prozac associated with reduced growth infants
1997 
11/00
 Case/Review Baby Prozac (withdrawal) side-effects: Hyperglycaemia (Elevated blood sugar)

TARDIVE DYSKINESIA/DYSTONIA, PARKINSONISM, EPILEPTIC SEIZURES, MEMORY PROBLEMS
2003 
12/00
 Case/Review Memory Loss in a patient treated with fluoxetine
2002 
00/00
 Case/Review Torticollis (deformity of the neck), Bradykinesia & Cogwheel Rigidity (muscle jerks)
2002 
05/14
 Case/Review Fluoxetine (Prozac)-induced tremor: clinical features in 21 patients
2002 
05/08
 Case/Review Fluoxetine-induced Exacerbation of Chorea (neurological movement disorder)
2001 
08/00
 Case/Review Myoclonus secondary to the concurrent use of trazodone and fluoxetine
2001 
07/00
 Case/Review Acute Paroxysmal Dystonia induced by fluoxetine
2001 
06/00
 Case/Review Dose-dependent Seizure Activity associated with fluoxetine therapy
2000 
03/02
 Case/Review SIADH with Epileptic Seizures and Coma in fluoxetine therapy
1998 
09/10
 Case/Review Tonic Clonic Seizures & Tachycardia induced by fluoxetine (Prozac) overdose
1998 
06/27
 Case/Review Severe Tardive Dyskinesia during treatment with risperidone and fluoxetine
1996 
10/00
 Case/Review Movement disorders associated with Selective Serotonin Reuptake Inhibitors
1996 
09/00
 Case/Review Tardive Dyskinesia associated with fluoxetine
1996 
05/00
 Case/Review Complex Movement Disorders induced by fluoxetine
1995 
10/00
 Case/Review Parkinsonism (future Parkinson's disease) associated with Prozac & cimetidine
1995 
08/00
 Case/Review Seizure after isolated fluoxetine-overdose
1995 
01/00
 Case/Review Worsening Tremor & Problems with Word-Finding following fluoxetine treatment
1994 
06/00
 Case/Review Fluoxetine induced Dyskinesia
1994 
05/00
 Case/Review Reversible Intermittent Rhythmic Myoclonus with fluoxetine in pres. Pick's disease
1993 
12/00
 Case/Review Seizures associated with fluoxetine therapy
1993 
01/00
 Case/Review Increase of Parkinson Disability after fluoxetine medication
1979 
00/00
 Case/Review Dystonic Reaction, Parkinsonian Rigidity & Increased Serum Prolactin levels

AKATHISIA, MANIA, SUICIDE & SELF-HARM, PERCEPTUAL-, EMOTIONAL & MENTAL STATE CHANGES
2004 
-2005
 MedicalFacts  Akathisia & Mania: can lead to suicidal, aggressive and/or homicidal behaviours
2004 
10/15
 FDA US  "BLACK BOX SUICIDE WARNING" ALL ANTIDEPRESSANTS including Prozac
2004 
09/14
 FDA US Antidepressant "BLACK BOX WARNING" On Suicidality Risk Recommended
2004 
05/18
 HealthCanada PROZAC WARNING: Risk of suicide, self-harm, behavioural/emotional changes
2004 
03/00
 Case/Review Hallucinations with zolpidem and fluoxetine in an impaired driver
2003 
12/00
 Case/Review Fluoxetine dose-increment related Akathisia in depression
2002 
07/08
 Case/Review High-dose fluoxetine-induced Mania. Review and case report
2002 
06/22
 Case/Review Akathisia due to the higher dose of fluoxetine -scroll to case 3
2001 
06/00
 Case/Review Mania & Paranoid Ideation following Tramadol-Fluoxetine Combination
2001 
03/00
 Case/Study Treatment-Emergent Behavioural Side-Effects in adults with learning disabilities
2000 
09/00
 Case/Review Melancholic Depression during concurrent olanzapine and fluoxetine
2000 
06/13
 Case/Study Occurrence of Deliberate Self-Harm highest with Fluoxetine (Prozac/Sarafem)
1998 
08/00
 Case/Study Manic behaviors with Fluoxetine in three 12- to 18-year-olds with OCD
1997 
00/00
 Case/Review Recurrent Toxic Delirium in a patient treated with fluoxetine & low dose trazodone
1995 
00/00
 Case/Review Fluoxetine: increased suicidal ideation and/or agitation have been reported
1995 
01/00
 Case/Review Reversible Delirium after discontinuation of fluoxetine
1994 
02/00
 Case/Review Fluoxetine and Violent Death in Maryland: violent methods in fluoxetine suicides
1994 
09/10
 Case/Review Revisiting Fluoxetine: Akathisia & Suicidal Preoccupations
1993 
12/00
 Case/Review Acute Hyperkinetic Delirium during fluoxetine treatment. A case report
1992 
11/00
 Case/Review Irritability, Self-Damage by Cutting & Violent Intense Suicidal & Paranoid Ideation
1992 
11/00
 Case/Review Akathisia, suicidality, and Prozac/Sarafem
1992 
07/00
 Case/Study Fluoxetine in autistic disorder: restlessness, hyperactivity, agitation, insomnia...
1992 
03/00
 Case/Review Mania associated with Prozac/Sarafem treatment in adolescents
1991 
12/00
 Case/Review Serious suicide attempts by 3 patients during treatment Fluoxetine: Akathisia
1991 
03/00
 Case/Review Emergence of self-destructive phenomena in adolescents & Prozac/Sarafem
1991 
03/00
 Case/Review A fluoxetine-induced Frontal Lobe Syndrome (Amotivational Syndrome) in OCD
1990 
02/00
 Case/Review Emergence of intense suicidal preoccupation during Prozac/Sarafem treatment
1989 
09/00
 Case/Review Prozac/Sarafem-induced Akathisia: clinical and theoretical implications
1984 
02/00
 Case/Review A case of mania associated with Prozac/Sarafem

SEROTONIN SYNDROME, NEUROLEPTIC MALIGNANT SYNDROME
2003 
05/27
 Case/Review Serotonin Syndrome: a brief review -case 1 fluoxetine
2002 
09/00
 Case/Review Neuroleptic Withdrawal vs Serotonergic Syndrome in 8-year-old child on fluoxetine
2002 
04/00
 Case/Review Case of a patient with Fluoxetine & Selegiline induced Fatal Serotonin Syndrome
2002 
02/00
 Case/Review Serotonin Syndrome present. as Hypotonic Coma & Apnea (fluoxetine & citalopram)
2000 
03/00
 Case/Review Serotonin Syndrome during fluoxetine-poisoning in a patient taking moclobemide
2000 
02/00
 Case/Review Case Report: Serotonin Syndrome with Serzone and Prozac
1995 
07/08
 Case/Review Serotonin Syndrome in a patient given fluoxetine and lithium
1994 
11/00
 Case/Review Serotonin Syndrome in 48-year-old man presented to emergency department
1990 
09/15
 Case/Review Fluoxetine (Prozac, Sarafem) and Neuroleptic Malignant Syndrome

BLOOD/ORGAN DISEASES, HEPATOTOXICITY (Liver damage), CARDIOVASCULAR TOXICITY (Heart damage)
2002 
12/00
 Case/Review Ecchymosis with Prozac (hemorrhage under the skin, sign of liver dysfunction)
1999 
11/00
 Case/Study Fluoxetine impairs the CYP2D6-mediated metabolism in healthy Chinese volunteers
1999 
11/00
 Case/Review Hyperthyroidism secondary to antidepressive treatment with fluoxetine
1999 
07/00
 Case/Review Acute Hepatitis due to fluoxetine therapy
1998 
09/10
 Case/Review Tonic Clonic Seizures & Tachycardia induced by fluoxetine (Prozac) overdose
1997 
09/00
 Case/Review Fluoxetine-induced Cardiotoxicity with response to bicarbonate therapy
1992 
09/00
 Case/Review Case report of a Syncopal Episode associated with fluoxetine
1990 
09/00
 Case/Review Fluoxetine-induced Bradycardia and Syncope in two patients

ABNORMALITIES IN BRAIN CELLS (Neurons) REPRESENTING NEUROLOGICAL TOXICITY (Brain damage)
2002 
04/15
 Bio-Study Neuronal Cell Death induced by Fluoxetine
2000 
02/29
 Animal Study Prozac & other SSRI's cause Shriveled & Corkscrew Shaped Brain Cells
1999 
09/25
 Animal Study Prozac Induces Muscle Contractions and has other Molecular Targets Part2
1998 
09/01
 Animal Study Brain cell (neuron) function in forebrain altered by prenatal exposure to Prozac
1997 
00/00
 Animal Study Prenatal exposure to Prozac can produce changes in brain serotonin (5-HT) neurons

PAIN & NUMBNESS, SWELLINGS, HORMONAL IMBALANCES, HYPONATREMIA & SIADH
2002 
03/00
 Case/Review Hyponatremia & SIADH associated with Sertraline and Fluoxetine: a case report
2001 
02/00
 Case/Review Reversible Galactorrhea & Prolactin Elevation related to fluoxetine use
2000 
00/00
 Case/Review Fluoxetine-induced Anaesthesia of Vagina and Nipples
2000 
03/00
 Case/Review Fluoxetine and grossly swollen muscles & oedematous
2000 
03/02
 Case/Review SIADH with Epileptic Seizures and Coma in fluoxetine therapy
1999 
03/00
 Case/Review Severe Hyponatremia during treatment with fluoxetine
1999 
02/00
 Case/Study Incidence and Risk Factors for Hyponatraemia with Fluoxetine in elderly people
1997 
00/00
 Case/Review Syndrome of Inappropriate Secretion of Antidiuretic Hormone in 2 elderly women
1996 
11/25
 Case/Review Hyponatraemia/Syndrome of Inappropriate Secretion of Antidiuretic Hormone
1996 
04/00
 Case/Review Fluoxetine: Syndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH)
1989 
00/00
 Case/Review Fluoxetine-overdose: Flu-like Symptoms, Urticaria & Angioedema

HYPOGLYCEMIA (low blood sugar), HYPERGLYCEMIA (high blood sugar, diabetes)
2004 
04/00
 Animal Study Hyperglycemia induced by acute central fluoxetine (Prozac) administration
2001 
01/00
 Animal Study Fluoxetine (Prozac) caused significant hyperglycemia after injection into the blood...
2000 
03/00
 Case/Review Loss of Hypoglycemia Awareness in Diabetic Adolescent during Fluoxetine therapy
1999 
10/15
 Animal Study SSRI's Fluoxetine (Prozac) & fluvoxamine (Luvox) induced hyperglycemia...
1997 
11/00
 Case/Review Baby Prozac (withdrawal) side-effects: Hyperglycaemia (High blood sugar, Diabetes)
1996 
11/00
 No Abstract Suggestive episodes of hypoglycemia related to fluoxetine (Prozac, Sarafem)
1996 
03/00
 No Abstract Hypoglycemia associated with the use of fluoxetine (Prozac)

OTHER OBSERVATIONS
2004 
09/00
 Case/Study Neonatal toxicity: Fluoxetine concentrations in cord & maternal serum
2004 
02/00
 Case/Study FDA's approval of fluoxetine for children was based on 2 controversial studies
2003 
11/07
 Case/Study Draft Report Prozac/Sarafem (fluoxetine) Toxicity in Humans
2002 
06/00
 Case/Study CYP2D6 genotype does not predict fluoxetine-induced Hyponatraemia
1999 
10/00
 Case/Study Distribution and excretion of fluoxetine and norfluoxetine in human breast milk
1999 
06/15
 AnimalStudy Augmentation of the Stimulus Effects of LSD by Fluoxetine in Rats
1997 
01/00
 Case/Study Fluoxetine and NorFluoxetine Plasma Concentrations in Major Depression
1993 
00/00
 Case/Review Fluoxetine: Adverse Effects and drug-drug Interactions

Prozac/Sarafem Articles
2004 
09/15
 Independent UK to ban Prozac after US FDA children suicide warning
2004 
09/15
 USA Today New Prozac study: 50% higher risk of suicide in children
2004 
09/12
 Denver Post Risks of Prozac: Link to violence not studied by FDA
2004 
09/06
 Houston Chron. Prozac concerns intensify: suicide & violence
2003 
11/03
 PFPC Prozac/Sarafem, Paxil/Seroxat & Fluoride Toxicity
2003 
06/05
 BBC News Prozac/Sarafem blamed for woman's death
2003 
06/03
 Leeds Today Professor Alistair Hay: "Prozac (sarafem, fluoxetine) killed my wife"
2003 
06/03
 TheGuardian Prozac/Sarafem 'led to wife's suicide'
2002 
03/27
 Independent Prozac Linked to Brain Tumours-Increased Cancer Growth Related Link Link(2)
2002 
01/24
 BBC News Health group's Prozac fears
2001 
08/26
 Indep.MediaCr Prozac Hangover
2001 
04/29
 Independent World Health Watchdog warns of Addiction Risk for Prozac/Sarafem users
2000 
00/00
 CERT Fluoxetine can have Serious Drug Interactions
2000 
05/22
 TheGuardian Prozac/Sarafem can bring on Impulse to Suicide Rel.Link Link(2)
2000 
05/09
 BostonGlobe Evidence Sheds New Light On Dark Side Of Prozac
2000 
05/07
 BostonGlobe 50,000 SUICIDES ON PROZAC COVERED UP
1999 
09/09
 Gary Null, Ph.D Side Effects Prozac: A Second Opinion
1995 
06/22
 James D. Hegarty Suicidal and Violent behavior during Fluoxetine treatment

 Anti-Depressant Neurological Side-Effects: Addiction & Withdrawal
 Anti-Depressant Neurological Side-Effects: Akathisia & Mania (Suicide & Aggression)
 Anti-Depressant Neurological Side-Effects: Serotonin Syndrome
 Anti-Depressant Neurological Side-Effects: Toxicity & Brain Damage
 Anti-Depressant Neurological Side-Effects: "Anecdotal" Reports -Personal Experiences

 Antidepressants: How To Wean/Taper Off
 Antidepressants: How to Survive a Negative Reaction
 Antidepressants: Conquering Depression and Anxiety

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